Antihypertensive and β-adrenoceptor antagonist action of timolol
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چکیده
منابع مشابه
Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis
Prazosin an α1-adrenoceptor (AR) antagonist has been shown to reduce liver injury in a mouse model of non-alcoholic steatohepatitis (NASH) and is suggested as a potential treatment of NASH especially given its concomitant anti-fibrotic properties. The effect however, of β-AR blockade in non-cirrhotic NASH is unknown and is as such investigated here. In the presence of the β-blocker propranolol ...
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متن کاملPolymorphism of the beta-2 adrenoceptor and IOP lowering potency of topical timolol in healthy subjects.
PURPOSE Beta-2 adrenoceptor antagonists such as timolol have been used in the treatment of glaucoma for more than 30 years. Several functionally important polymorphisms for the beta-2 receptor have been described. In the present study we hypothesized that a relation between the intraocular pressure (IOP) lowering effect of timolol and beta-2 adrenoceptor polymorphisms may exist. METHODS A tot...
متن کاملAntihypertensive and hemodynamic properties of the new beta adrenergic blocking agent timolol.
The antihypertensive activity of timolol, a new beta adrenergic blocking agent, was assessed in hypertensive patients. In hospitalized patients timolol, 5 mg orally every 8 hr for one week, resulted in a significant although mild reduction of blcod pressure with diastolic pressure falling from a mean of 101 mm Hg to 91 mm Hg. Heart rate and cardiac output fell while total peripheral resistance ...
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ژورنال
عنوان ژورنال: Clinical Pharmacology & Therapeutics
سال: 1978
ISSN: 0009-9236
DOI: 10.1002/cpt1978232152